Medication non-adherence is a complicated and common problem. It is estimated that 3 out of 4 Americans do not take their medication as directed. Approximately 50% patients do not take there medications as prescribed. This poor adherence to medication leads to increased morbidity rates and death. poor medication adherence takes the lives of 125,000 Americans annually, and costs the health care system nearly $300 billion a year in additional doctor visits, emergency department visits and hospitalizations.